A meta-analysis on the association of the codon 72 polymorphism in p5 3 gene with the cervical cancer in Chinese population / 预防医学

Objective To evaluate the association of cervical cancer and the G/C single nucleotide polymorphism at codon 72 in p53 gene exon -4 in Chinese population.Methods Literatures were searched in CNKI,VIP,CBM, PubMed,EMBase,the Cochrane Library (Issue 1,2015),WanFang Data Database (1980—2015)with computer. Results Thirteen studies involving 1 780 cervical cancer patients and 1 5 17 healthy volunteers were included.According to the situation of the HPV infection in research object,thirteen studies were divided into two subgroups.The results of meta-analyses in the subgroup of non-HPV infection showed that the Chinese women having the genotype G/G presented no increased relative risk compared to that with the genotype C/C(OR=0.980,95%CI:0.558 -1.723).The allele G showed no increased relative risk compared to the allele C (OR=1.070,95%CI:0.789-1.449)The results of meta-analyses in the subgroup of HPV infection showed that the Chinese women having the genotype G/G presented no increased relative risk compared to that with the genotype C/C(OR=0.891,95%CI:0.213 -3.722).The allele G showed no increased relative risk compared to the allele C (OR =0.981,95%CI:0.493 -1.951 ).Conclusion This meta -analysis demonstrates that G/C single nucleotide polymorphism at codon 72 in p53 gene exon-4 were not associated with cervical cancer in Chinese women.

An analysis on the high risk factors of pelvic lymph node metastasis in cervical carcinoma patients / 预防医学

Objective To investigate the metastatic risk factors of pelvic lymph nodes in patients with cervical carcinoma of stage Ia2 and IIa2.Methods The clinic opathologicparameters in 337 patients with stage Ia2 -IIa2 cervical carcinoma were retrospectively analyzed,and were studied the related factors of pelvic lymph node metastasis.Results The lymph nodes metastasis rate was 11.87%,with the obturator and internal iliaclymph nodes mostly involved.Multivariate analysis showed that the myometrial invasion,size of tumor,lymph -vascular space involvement and utero -tissue infiltration were major risk factors.The OR value and 95%CI were 3.464(1.502 -7.985)、4.316 (1.164 -7.833)、6.167 (2.592 -14.674)和 8.507(1.966 -36.808)respectively.Conclusion The myometrial invasion≥ 2 /3,size of tumor≥ 4 cm, lymph -vascular space involvement and utero -tissue infiltration positive lymph node metastasis of cervical cancer are easy to occur.